M. N. Kalinkin

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In the myocardial mitochondria (MCh) of persons who had died from ischemic heart disease (IHD) the content of phosphatidylcholine (PCh) and cardiolipin reduces while the amount of the products of their hydrolysis--free fatty acids (FFA) and lysophospholipids--increases. This is evidence of the breakdown of the membrane MCh phospholipids (PL). The content of(More)
AIM To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion. MATERIAL AND METHODS The study enrolled 52 patients with postinfarction cardiosclerosis (PICS). Clinical,(More)
Large intestine microbiocenosis, levels of endotoxinemia, tumor necrosis factor alpha, C-reactive protein, sE-selectin, matrix metalloproteinase-9 (MMP) and tissue inhibitor of metalloproteinases-4 (TIMP) in chronic heart failure (CHF) patients was studied. Association of dysbiosis and endotoxinemia levels increase, systemic inflammation activation and an(More)
Comparative study of content of main lipid fractions was carried out in five parts of rabbit myocardium by means of thin-layer chromatography on silicagel with subsequent quantitative estimation. Increased concentrations of free and esterified cholesterol, free fatty acids and triglycerides were observed in atrium dextrum and triglycerides in ventriculus(More)
The aim of this work was to study colonic microbiocenosis, endotoxin level, intensity of systemic inflammation and the state of matrix metalloproteinase (MMP) system and MMP tissue inhibitors (TIMP) in 75 patients with post-infarction cardiosclerosis at different stages of chronic cardiac failure (CCF). The patients were examined by clinical,(More)
Disorders of lipid catabolism in the liver and increased formation and intensified secretion into the blood of lipoproteins synthesized in the liver evidently play a significant role in the maintenance of experimental atherogenic hyperlipoproteinemia induced in rabbits by prolonged administration of atherogenic lipoproteins.
Lipidogramms of various parts of myocardium of the persons, decreased in acute alcoholic intoxication, were characterized by an increase in content of triglycerides, free fatty acids free and esterified cholesterol. Content of phospholipids in the myocardium was unaltered. Concentration of atherogenic lipoproteins, phospholipids and triglycerides was(More)
Type IV hyperlipoproteinemia and sharp increase in the concentration of free fatty acids in blood were revealed in most individuals who had died suddenly of ischemic heart disease. Beside increased lipolytic activity of the myocardium, accumulation of free fatty acids and triglycerides in the muscle tissue of the heart was revealed. The authors presume that(More)