M. Mumtazuddin Ahmed

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A study has been made of synaptic degeneration at an ultrastructural level using 6% glutaraldehyde perfusion, fixation method in the anterior horn of hen's spinal cord, after application of a single dose of 0.5 cm3 TCP on the comb. The degenerative changes are seen in the synaptic vesicles and mitochondria of pre-synaptic bag. A comparison of these findings(More)
In search of better NSAIDs four novel nitric oxide donating derivatives of curcumin (compounds 9a-d), and four thiophene curcuminoids (compounds 10a-c, 11) have been synthesised. The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and(More)
Biopsies from 5 cases of Juvenile Laryngeal Papilloma were studied by electron microscopy. In 2 cases, phagocytosed neutrophils were seen in various stages of degeneration and disintegration within the neoplastic cells. The possible phenomenon of "emperiopolesis' and "phagocytosis' in a benign neoplasm is described, and it is suggested that all cases of(More)
Electron microscopy of Juvenile Laryngeal Papilloma from Nigerian children has revealed the presence of nuclear bodies in the neoplastic cells. These bodies were round or oval in shape and varied from 0.3 to 0.5 micrometer in diameter. The immature forms consisted of fine fibrous units, whereas the mature forms displayed central and peripheral zones. The(More)
Toxic reaction of satellite cells from posterior root ganglia of slow loris in TCP poisoning is described. The satellite cells in experimental animals show a marked increase in the rough ER, Golgi complex, microvesicles and filaments. Furthermore there is also an increase in the number of dense bodies and mitochondrial density in these cells. The(More)
The neurotoxic effects of tricresylphosphate (TCP) in slow loris (Nycticebus coucang coucang) pro simian primate are reported. The external application of 0.2 cm3/kg body weight of TCP daily for 10 days on the skin of the neck produced general symptoms of intoxication. First there were gastro-intestinal disturbances which were followed by marked ataxia and(More)
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