M. Monjur Ahasan

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OBJECTIVES Synovial fibroblasts and osteoblasts generate active glucocorticoids by means of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme. This activity increases in response to proinflammatory cytokines or glucocorticoids. During inflammatory arthritis synovium and bone are exposed to both these factors. This study hypothesised that(More)
OBJECTIVE Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in(More)
T-cell immunity is important for controlling Kaposi sarcoma-associated herpesvirus (KSHV) diseases such as the endothelial cell malignancy Kaposi sarcoma, or the B-cell malignancy, primary effusion lymphoma (PEL). However, little is known about KSHV-specific T-cell immunity in healthy donors and immune control of disease. Using PBMCs from healthy(More)
Murine cytomegalovirus mutant Rc29, with a premature stop codon mutation in the m29 open reading frame (ORF), produced no apparent phenotype in cell culture or following infection of BALB/c mice. In contrast, a similar mutant virus, Rc29.1, with a premature stop codon mutation in its m29.1 ORF, showed reduced virus yields (2-3 log(10) p.f.u. ml(-1)) in(More)
T-cell immunity is important for controlling Kaposi sarcoma–associated herpesvirus (KSHV) diseases such as the endothelial cell malignancy Kaposi sarcoma, or the B-cell malignancy, primary effusion lymphoma (PEL). However, little is known about KSHV-specific T-cell immunity in healthy donors and immune control of disease. Using PBMCs from healthy(More)
A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44,827 of the Smith MCMV BAC, was attenuated in replication both in tissue culture and in SCID mice. Similarly,(More)
A retrospective study has been conducted on 19 patients who attended at CNMU, Rajshahi with differentiated thyroid cancer, treated with radioiodine for ablation of residual tissue after thyroidectomy. The patients included in this study were between 06 to 70 years of age, the mean age being about 36 years. The main objective of the study was to evaluate the(More)
Scatter fraction (SF) characteristic of a newly constructed 16-ring PET system with a FOV of 20 cm was experimentally evaluated in 2D acquisition mode (ring difference ≤ 3) but without septa, using a 10 cm diameter phantom. The scatter fraction measured from the backprojected images and the sinogram data aiming to find the discrepancy between the two(More)
Dual Energy X-ray Absorptiometry (DXA) has long been and remains the most widely used technique for Bone Mineral Densitometry (BMD) measurement. Several manufacturers developed their performance of DXA with various types of measurement software but still not a unique data processing system which can ensure the unique measurement for the patients. The aim of(More)