M. Midori Ikeda

Learn More
Effective methods for eradicating cancer stem cells (CSCs), which are highly tumorigenic and resistant to conventional therapies, are urgently needed. Our previous studies demonstrated that survivin-responsive conditionally replicating adenoviruses regulated with multiple factors (Surv.m-CRAs), which selectively replicate in and kill a broad range of(More)
Using the delta-enriched mouse vas deferens and the kappa-enriched guinea-pig ileal longitudinal muscle preparations, a large variety of so-called 'mu, kappa, delta and sigma' opioid agonists were tested for their mu, kappa and delta properties. Buprenorphine and U50,488H appeared to be the most highly selective agonists for mu and kappa opioid receptors,(More)
Bruxism is associated with an increase in the activity of the jaw-closing muscles during sleep and wakefulness. However, the changes in jaw-closing muscle activity across states of vigilance over a 24-h period are unclear. In this study, we investigated the effects of dark/light transition and sleep/wake state on EMG activity of the masseter (jaw-closing)(More)
In this study, we investigated the effects of chronic administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on sleep/wake cycles and masseter (jaw-closing) muscle electromyogram (EMG) activity over a 24-h period. From the dark to the light period, the times of wakefulness decreased, while those of non-rapid eye movement (NREM) and(More)
In this study, we first measured some cytokine concentrations in the serum of patients treated with Juzentaihoto (JTT). Of the cytokines measured interleukin (IL) -18 was the most prominently up-regulated cytokine in the serum of patients under long term JTT administration. We next evaluated the effects of JTT in mice, focusing especially on natural killer(More)
  • 1