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In order to determine the effect of lidocaine in focal cerebral ischemia, the left middle cerebral artery was transorbitally occluded in twenty cats. Eleven received lidocaine hydrochloride intravenously. The infusion was begun half an hour prior to clip occlusion and the rate was adjusted to maintain an isoelectric EEG. Nine cats served as controls,(More)
It has recently been suggested that severed axons fail to regenerate in the mammalian central nervous system as a result of an autoimmune reaction to myelin basic protein released into the circulation at the time of injury. Since the autoantigenic components of peripheral myelin are rapidly phagocytosed after axonal transection, it is claimed that a(More)
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