M. McDonnell

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BACKGROUND It is unclear if it is safe for babies to bed share with adults. In Ireland 49% of sudden infant death syndrome (SIDS) cases occur when the infant is bed-sharing with an adult. OBJECTIVE To evaluate the effect of bed-sharing during the last sleep period on risk factors for SIDS in Irish infants. DESIGN An 8 year (1994-2001) population based(More)
Electrospray mass spectrometry (ES/MS), capillary-zone electrophoresis (CZE), capillary isoelectric focusing (CIEF), and multianalyte resonant mirror are used to evaluate the heterogeneity of samples of ricin toxins extracted from five horticultural varieties of Ricinus communis seeds: R. communis zanzibariensis, carmencita, impala, sanguineus, and(More)
Cholesteryl ester transfer protein (CETP) has a well-defined role in plasma neutral lipid transport. CETP synthesized by human adipose tissue may contribute to the plasma CETP pool. CETP mRNA abundance increases in subcutaneous adipose tissue in response to cholesterol feeding and we have hypothesized that CETP gene expression is regulated by a specific(More)
BACKGROUND The International Child Care Practices Study (ICCPS) has collected descriptive data from 21 centres in 17 countries. In this report, data are presented on the infant sleeping environment with the main focus being sudden infant death syndrome (SIDS) risk factors (bedsharing and infant using a pillow) and protective factors (infant sharing a room(More)
We have determined the role of cholesteryl ester transfer protein (CETP) in selective uptake of high density lipoprotein (HDL)-derived cholesteryl esters (CE) by human adipose tissue, using organ culture or collagenase-digested adipocytes. Incubation of the fresh tissue fragments with HDL containing [3H]CE or 125I-apoprotein (apo) A-I resulted in(More)
In March 1992 the 'Reduce the Risk of Cot Death' guidelines were launched in the Republic of Ireland. In response to epidemiological surveys conducted in 1993 and 1994 these guidelines were revised in November 1995 and a new leaflet was distributed. The study set out to compare parents interviewed in 1994 (n = 153) and 1996 (n = 132) to determine their(More)
BACKGROUND Infant necropsies are important for identifying cause of death. Recently issued guidelines have recommended investigations to be performed following sudden unexpected death in infants. AIMS To evaluate the quality and value of infant postmortem reporting. METHODS Postmortem reports from 1994-1996 and 1998-2000 in Ireland were evaluated using(More)
AIM To identify risk factors for sudden infant death syndrome (SIDS) in the sleeping environment of Irish infants. METHODS A five year population based case-control study with parental interviews conducted for each case and three controls matched for age, place of birth, and last sleep period. A total of 203 SIDS cases and 622 control infants born 1994-98(More)