M Mandrino

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1. A late inward current following the initial sodium current is sometimes observed on frog single skeletal muscle fibres studied in voltage-clamp conditions by the double sucrose-gap method. 2. The late inward current is time and voltage dependent; it is sensitive to extracellular sodium concentration and inhibited by tetrodotoxin. Therefore, it is very(More)
We used the polymerase chain reaction (PCR) and allele-specific-oligonucleotide hybridization (ASO) or restriction enzyme analysis (RE) to investigate the molecular defect in 100 Italian subjects heterozygous for beta-thalassemia, members of 50 couples at risk for the disease: 93 out of the 100 alleles studied were identified after investigating 9 known(More)
Serum vitamin E values are depressed in thalassaemia owing to increased consumption because of the oxidative stress imposed both to red cells and other tissues by haemochromatosis. A study of vitamin E deficiency was carried over a period of about 2 years in 161 transfusion dependent thalassaemic patients aged 4 months to 18 years (including 74(More)
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