M. M. Ushakova

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Experiments were made on female rats to demonstrate a positive correlation between the time of ethanol anesthesia in estrus and diestrus and (1) subsequent preference of ethanol to water (r = 0.68) and (2) ethanol consumption dosage (r = 0.72). In the same rats (during estrus and diestrus), the endogenous level and blood concentrations of ethanol were(More)
The influence of apomorphine (1 mg/kg/day subcutaneously) on the behavior and some pharmacokinetic parameters of both male and female rats preferring ethanol to water was studied experimentally. Upon withdrawal of ethanol, apomorphine decreased the time of transmission to water consumption in the rats of both sexes and prevented a decline in the endogenous(More)
It has been shown in non-alcoholized male rats that castration significantly and appreciably raises the level of endogenous ethanol. In chronic alcoholization of castrated and non-castrated rats, the rate of ethanol elimination (REE) is noticeably increased, with testosterone producing no essential effect on the REE. In the liver, alcohol dehydrogenase(More)
Blood concentrations of endogenous ethanol (EE) reflects the effects of various psychic and medicinal impacts. EE levels in alcoholic patients depend on the severity of alcoholism, emotional status and efficacy of treatment. Actualization of the pathologic craving for alcohol and other types of emotional excitement are attended by reduced EE concentrations(More)
Studies of the pharmacokinetics of ethanol in the blood and exhaled air and of acetaldehyde in exhaled air in rats of different sexes have shown that in the group of normal animals, the level of endogenous ethanol and maximal blood concentration of ethanol administered in the test dose (2.2 g/kg) was higher in females than in males. The decrease of ethanol(More)