M M Tanashian

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A high level of mortality and disability makes study of various aspects of ischemic cerebral stroke (ICS) an extremely important problem. Presently, combination of various cardiovascular risk factors significantly increases the probability of such life-threatening conditions as ICS. Such risk factors as arterial hypertension, dyslipoproteinemia, excessive(More)
This review concerns clinical and laboratory resistance to antiplatelet drugs (aspirin and clopidogrel) in patients with cerebrovascular disorders. Results of certain clinical trials showed that laboratory resistance to antiaggregants is associated with recurrent thromboembolic vascular events. The commonest causes of aspirin resistance are production of(More)
An assessment of the complex multicenter prospective non-comparative program aimed at studying of efficacy and safety of a new scheme of therapy with cavinton in patients with chronic cerebrovascular insufficiency has been conducted. One hundred and forty-nine patients (46 male, 113 female), aged from 35 to 65 years, have been examined. The treatment(More)
Associated changes in the characteristics of local cerebral blood flow (CBF) and slow brain electrical activity were studied in 40 patients with dyscirculatory encephalopathy. CBF and CBV (cerebral blood volume) values for the frontal and temporal cortex and basal ganglia positively correlated with the constant potential values in the central lead(More)
The article addresses theoretical and practical issues of using diffusion- (DW-MRI) and perfusion-weighted (PW-MRI) magnetic resonance tomography in acute period of ischemic stroke. The authors consider prognostic value of the results obtained with both methods of MRI-diagnosis and possibilities of their usage in pathophysiological studies of ischemic(More)
An electron-microscopic study of the response of cochlear stria vascularis (CSV) cells to an electric impact of physiotherapeutic parameters was made in 26 guinea-pigs. Twelve guinea-pigs (group 1) have undergone 9 sessions of bilateral endaural electrostimulation with square bipolar impulses (4 ms, 0.1-0.4 mA, 50 Hz, 20 min). Fourteen guinea-pigs of group(More)
AIM to study an association between metabolic syndrome and endothelial dysfunction as a regulator of hemorrheological and hemostatic processes in patients with chronic forms of cerebral circulatory insufficiency. SUBJECTS AND METHODS Forty-six patients with chronic cerebrovascular diseases (CCVD) were examined; of them 23 patients were diagnosed as having(More)
AIM To study various aspects of cerebrovascular diseases (CVD) in the presence of metabolic syndrome (MS). SUBJECTS AND METHODS A comprehensive clinical, laboratory, ultrasound, and neuroimaging study was conducted in 514 patients with symptomatic and asymptomatic atherosclerotic lesion of the internal carotid artery and MS. RESULTS MS was found and(More)
Considerable disturbance of all quality of life domains that worsens social adaptation and daily living and results in an asthenic-neurotic syndrome, along with neurologic and mnestic-intellectual disturbances, was revealed in patients with chronic brain ischemia (stages I, II, III). Based on the results of the double blind placebo-controlled trial, the(More)
AIM Study of the tolerance and pharmacodynamic and pharmacokinetic characteristics of ascolong, a new buccal dosage form of aspirin containing a very low dose of acetylsalicylic acid (ASA): 12.5 mg. MATERIALS AND METHODS The study was carried out in 43 healthy men (assessment of the drug tolerance) and 19 male patients with coronary disease or(More)