M. M. Svinov

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The pharmacological efficacy of cerebrolysin (a brain-derived peptidergic drug) was studied in rats with a unilateral hemorrhagic stroke model. Cerebrolysin produces a neuroprotective effect, which is manifested by a decrease in the number of degenerated neurons in the vicinity of hematoma region in acute period and by a reduction of the neuronal loss in(More)
The effect of the new drug "cerebral" and its fractions 1-3 on the model of bilateral hemorrhagic stroke in white rats was studied with reference to the action of cebrolysin and cerebrolysate-M. With respect to the general functional state, behavioral activity restoration, and morphological data, the most pronounced antistroke action was observed for the(More)
The method of stopped flow was used to follow the changes in light scattering by the vesicles of plasmalemma and tonoplast isolated from maize (Zea maysL.) roots and treated by osmotic pressure. In both membrane preparations, the rate of the process depended on the osmotic gradient and was described with the simple exponential function. The rate constants(More)
6 According to the traditional concepts, olfactory chemoreceptor neurons generally have a stable mor phological organization and functional specificity [1]. However, study of adaptive recombination in the olfactory system of endemic Baikal fish (Cottocome phorus grewingki, Dyb), the phenomenon of chemore ceptor differentiation into cells of secretory type(More)
According to modern views the formation of atherosclerotic plaques is associated with accumulation of cholesterol in the vascular wall. This is due to an imbalance between the intake of cholesterol in the intima of vessels, together with the low-density lipoproteins (LDL) and its output with high-density lipoprotein (HDL). Change of LDL (glycosylation,(More)
A standardized experimental model of intracerebral hemorrhagic stroke in small laboratory animals is developed and advanced for chronic neurobiological studies of normal and pathological higher nervous activity as well as disorders developed after acute hemorrhages. A device is advanced which allows a researcher to destroy appropriate brain structures(More)
We studied the role of cholinergic systems of the rat brain in the mechanisms of acute response of the neocortex and hippocampus to acute hypobaric hypoxia. The activity of choline acetyltransferase and Na/K-ATPase and the protein content were measured in subfractions of synaptic membranes and the synaptoplasm of “light” and “heavy” synaptosomes. The same(More)
Quantitative analysis of synapses in layer I of the sensorimotor cortex in rats with low resistance to hypoxia revealed pronounced changes in the number of synaptic vesicles docked at the presynaptic membrane in active synaptic zones under conditions of acute hypobaric hypoxia. In high-resistant animals the number of docked synaptic vesicles under these(More)
The electroencephalogram (EEG) is a widely used indicator of the state of brain function. It can reflect gross, and frequently irreversible, brain lesions, and is widely used for this purpose in neurology [4]. However, virtually no information is so far available on correlation between the E E G and reversible microstructural changes in single brain cells(More)
Structural changes in the sensorimotor cortex of the cerebral hemispheres were studied in rats with experimental hemorrhagic stroke in the internal capsule. Changes in the shape and decrease in the density distribution of spines on apical dendrites of layer V pyramidal neurons of the sensorimotor cortex were revealed. Some fractions isolated from the(More)