M. M. Santarem

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Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Turbot were injected with the adjuvant prior, at the same time and after the vaccine. Several immune parameters (index and rate of phagocytosis, passive haemolytic plaque numbers, and agglutinating antibody titers) were(More)
C57BL/6 mice thymectomized as adults or depleted of CD4+ cells were much less susceptible than intact conventional mice to the B-cell mitogenic and specific immunosuppressive effects of a protein designated as F5'EP-Sm secreted by Streptococcus mutans. These mice were also considerably more resistant to infection by these bacteria than intact individuals.(More)
Santarem. M.M., Figueras. A.J., Robledo, I.A.F. and Caldas, J.R., 1992. Variation of the defence mechanisms in two groups of mussels, Myths galloprovincialis Lmk. Seasonal and environmental effects preliminary results. Aquaculture, 107: 181-188. Hemolymph parameters of mussels from two locations in the Ria de Vigo (N.W. Spain) were studied. Hemolymph(More)
The levels of carbohydrate and protein in the blood serum of mussels (Mytilus galloprovincialis Lmk.) experimentally cultured at two depths in Galicia (NW Spain) were determined over a period of 1 year. The changes in concentration of total and reducing carbohydrate and protein exhibited an annual cycle; their values varied from 0.053 to 0.700 mg/ml, from(More)
A noncytotoxic protein substance, produced by Streptococcus intermedius, with very potent immunosuppressive properties (F3'EP-Si) was tested for lymphocyte mitogenic activity. Although devoid of T-cell mitogenicity, F3'EP-Si stimulated proliferation and led to high numbers of plaque-forming cells in cultures of normal or T-cell-depleted, small or large(More)
Crude extracellular products of the Streptococcus intermedius "CEP-Si" were able to strongly decrease the in vitro proliferation of stimulated human peripheral blood mononuclear cells (HPBMC) when evaluated by (3H)-thymidine and (3H)-leucine uptake. On the other hand, CEP-Si only slightly decreased this proliferation when HPBMC were either not stimulated or(More)
Crude extracellular products of Streptococcus mutans (CEP-Sm) suppress the proliferative response to phytohaemagglutinin of human peripheral blood mononuclear cells and the primary immune response of C57BL/6 mice to sheep erythrocytes. This immunosuppressive effect favours the survival of the microorganism, and the bacteria lose the ability to secrete(More)
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