M. M. R. Young

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UNLABELLED Matrix proteoglycans define matrix structure, mineralization, and resulting biomechanics of tissues and their attachment sites. OBJECTIVE We therefore investigated physical and (bio)chemical differences in enamel and periodontal tissues/attachment sites from mice that lack a specific nanoscale small leucine-rich proteoglycan (SLRPs) named(More)
Histological examination of a tumor centered in the body of the pancreas of a 65-year-old Iranian man revealed it to have a substantial component in which osteoclast-like giant cells were set within a stroma of pleomorphic mononuclear cells though other areas were composed of conventional adenocarcinoma. Immunocytochemistry was used to investigate the(More)
Purpose: Complete resection of the tumor nodule(mural nodule or solid portion of the tumor) is the essential goal of surgical treatment for hemangioblastoma. The purpose of this study was to classify the morphologic types of intracranial hemangioblastoma on MRI and to compare the location and contour oftumor nodule on MRlwiththoseon angiography. Materials(More)
The level of plasma non-esterified fatty acids (NEFA) was measured by gas-liquid chromatography (GLC) and a titration method in 194 samples collected during pregnancy and from four days to 24 weeks post partum. Both techniques indicated a similar pattern of changes in plasma NEFA associated with pregnancy. The titration estimates of NEFA level were usually(More)
The relationship between maternal and fetal plasma glucose concentrations and placental glucose transfer has been studied in the anaesthetised guinea pig. The fetal circulation of the placenta, left ‘in situ’, was perfused through the umbilical arteries, after removal of the fetus, with a low molecular weight dextran, containing physiological salts and 100(More)
Changes in plasma nonesterified fatty acids (NEFA) and serum glycerol in pregnancy were examined in a semi-serial study of 85 women. A preliminary study showed that it was almost impossible to achieve standardized conditions for sampling, and the compromise of taking a single venous sample without stasis, after 30 minutes rest and about 12 hours fasting,(More)
The oxidative modification of low density lipoprotein is of importance in atherogenesis. Antioxidant supplementation has been shown, in published work, to increase low density lipoprotein resistance to oxidation in both healthy subjects and diabetic subjects; in animal studies a contemporary reduction in atherogenesis has been demonstrated. Troglitazone is(More)
Objective: Troglitazone is a new anti-diabetic agent for the treatment of type 2 diabetes. In placebo-controlled trials troglitazone improves glycaemic control, reduces hyperinsulinaemia and has beneficial effects on blood lipids. However, minor, reversible reductions in erythrocyte count, haemoglobin and haematocrit with no associated clinical symptoms(More)
Dear Sir, In their recent paper Young et al. [1] question the utility of the systolic ankle/brachial Doppler pressure index (ABI) in patients with diabetes mellitus, because a considerable proportion of these will have falsely elevated ankle/brachial index ABI due to medial arterial calcification (MAC) [2]. We would take issue with this generalization, and(More)
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