M. M. Kruchek

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OBJECTIVE To study the efficacy and tolerability of agomelatine (valdoxan) in treatment of mild depressive states in patients with chronic brain ischemia (CBI). MATERIAL AND METHODS The study comprised 33 patients (23 women, 10 men, average age 54.5 years), including 12 people (36.4%) with CBI, stage I, and 21 (63.6%) with CBI, stage II. All patients had(More)
Objective – to study the efficacy and tolerance of agomelatine (Valdoxan) in mild depressive states in patients with chronic cerebral ischemia (CCI). Materials and methods. The study included 33 patients (23 women, 10 men, mean age 54.5 years). Grade I CCI was diagnosed in 12 patients (36.4%) and grade II in 21 (63.6%). All patients had single depressive(More)
AIM To study activity of genetically programmed cell death (PCD) of lymphocytes in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS Lymphocytes from 30 RA patients including 14 patients with RA history up to 2 years, and 12 healthy donors were studied for activity of caspase 4, 6, 8 usingfluorescence and caspase substrates 30, 60, 120, 150(More)
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