M. M. Khananashvili

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The article is dedicated to P.S. Kupalov, due to his 120 Anniversary. P.S. Kupalov was the disciple of I.P. Pavlov and his nearest collaborator. Right after I.P. Pavlov, he was at the head of the Institute of Experimental Medicine in St-Petersburg, where he developed a number of new ideas, concerning conditioned reflexes. Thus, he discovered shortened(More)
Experiments on animals (rodents, beasts, primates) and observation in man have ascertained that psychogenic stress is the most important defensive state of living organisms, which is constantly involved in order to maintain their interaction with external psychogenic factors. Three types of stress should be distinguished, these include normostress,(More)
Established that one of the factors promoting development of the psycho-nervous diseases, are various kinds of social deprivation. The purpose of this study was investigation of importance of social interactions at the early period of postnatal in development of resistance of the nervous system against the psychogenic stress in the adult rats. At weaning,(More)
Trace processes in the neuronally isolated cerebral cortex of one hemisphere were analysed. EEG and unit activity of the isolated cortex at different times after the operation were investigated. Temporal connections in the isolated cortex were elaborated. Neurons fixing the stimuli traces were revealed. These neurons (23 percent of reactive neurons) form a(More)
The aim of our research was to study behavioral indices of rats standing on various hierarchical level in the conditions of acute informational stress as well as their resistance to stress taking into account their social status. The Animal's behavior has been studied in conflict and agonist conditions against the background of high food and thirst(More)
New approaches to optimization of interpersonal relationships in an isolated small group proposed in this paper can be applied to a manned mission to Mars. Some of these approaches have been tested in the course of preparation and implementation of an experiment with a 105-day isolation (the MARS-105 project) simulating the initial period of a manned(More)
A new model of depression based on use of stressors of the psychogenic nature has been created. It turned out that laboratory rats in a special stress-camera were unable to elaborate bilateral reaction of active avoidance, which later on led to formation of their depression-like state. Development of such their state was confirmed by analysis of tests(More)
The problem of adequate animal model of depression still remains. In our experiments depression-like condition on white rats were reached by the chronic stressors of psychogenic nature. Stress was carried out in a modified shuttle chamber of active avoidance. At the very beginning of the study (the first stage of stress) an animal was forced to develop a(More)
During last decades abnormalities of neuro-psychic sphere have become a topic of great interest. Among them an important place takes depression. Psychogenic factors are commonly the most frequent cause of depressive condition, and till now the study of so-called transitional period (from the beginning of stressor action till the formation of depressive(More)
The goal of the work was to study behavior of rats in conditions of psychogenic stress on the background of ethanol intake. Experiments were carried out on 12 mature while rats weighing 150-200g. Before the beginning of the experiments during one month rats with high and low ethanol intake have been identified. Conditioned reflexes of active avoidance of(More)