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Therapeutic activity, pharmacokinetic and bioavailability on animals (inbred white mouse, rabbits) were evaluated for Ofloxacin-PhPO and Pefloxacin-genova in comparison with innovator products--Tarivid and Abaktal. The results of the experiments demonstrate that investigated generics by their therapeutic efficacy in animals and by bioavailability are… (More)
Prolonged administration of guanethidine (20 mg/kg) to newborn rats caused a marked reduction in the number of cells in stellate ganglia. The administration of guanethidine for 14 days decreased the amount of cells to 30% of the normal (partial sympathectomy), and for 28 days--to 0.5% (complete sympathectomy). At the age of two months the blood pressure… (More)
Pharmacokinetics and bioavailability of the antimycotics ketoconazole FPO and fluconazole (Russia) and the analogous drugs nizoral (Belgium) and diflucan (France) were comparatively studied on animals and in clinical trials. The pharmacokinetic parameters of the drugs were determined and their bioequivalence was shown (90-110%) that is evident of their… (More)
It was shown that 3,12-b-dimethyl-octahydroindol-(2,3-a) quinolyzine (at the dose of 1/6 of LD50) exerted an antialcohol effect in mice and rats which is probably due to an increased content of the brain 5-hydroxytryptamine resulting from selective inhibition of its deamination.
The amount of cells in stellate ganglia of rat was decreased by chemical sympathectomy to 30% of the normal amount. At the age of two months sympathectomized rats have no pressor reflexes to asphyxia and femoral nerve stimulation. These responses are restored at the age of four months. The electron-microscopic and fluorescence-microscopic data show that the… (More)