M. Lopez

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BACKGROUND Cdc42 and other Rho GTPases are conserved from yeast to humans and are thought to regulate multiple cellular functions by inducing coordinated changes in actin reorganization and by activating signaling pathways leading to specific gene expression. Direct evidence implicating upstream signals and components that regulate Cdc42 activity or for(More)
Fn this paper; two techniques to reduce the energy and the average power consumption oj the system are proposed. They are based on the fact that as lhe tesL pragresses, the detection eficiency of the pseudo-rundom vectocrs decreases very quickly. Many of Lhe pseudo-random vectors vi11 not detect faults in spile of consuming a signiJicant arnomt of energy(More)
From beginning of 1994 to the end of 1996, the IRO-DB ESPRIT project has developed tools for accessing relational and object-oriented databases in an integrated way. The system is based on the ODMG standard as pivot model and language. It consists of three layers. The local layer provides for an ODMG interface to heterogeneous DBMSs, the communication layer(More)
PURPOSE Patients with advanced GIST following standard imatinib and sunitinib often have good performance status and need additional therapy. This study tested nilotinib, a second-generation tyrosine kinase inhibitor, in patients with advanced GIST refractory to standard therapies. METHODS This single-center open-label phase II study has a primary(More)
The specificity of the tube LAI in breast cancer was examined in a study with coded samples of PBL. In addition, 64 patients with breast cancer had their LAI reactivity monitored and correlated with their clinical status for up to 3 years after mastectomy. When patients were assayed by tube LAI, 83, 72, and 29% with Stage I, and II and III breast cancer(More)
Purpose. To compare the characteristics of asymmetric keratoconic eyes and normal eyes by Fourier domain optical coherence tomography (OCT) corneal mapping. Methods. Retrospective corneal and epithelial thickness OCT data for 74 patients were compared in three groups of eyes: keratoconic (n = 22) and normal fellow eyes (n = 22) in patients with asymmetric(More)