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The pharmacokinetics and metabolism of nateglinide were studied in six healthy male subjects receiving a single oral (120 mg) and intravenous (60 mg) dose of [14C]nateglinide in randomized order. Serial blood and complete urine and feces were collected for 120 h post dose. Nateglinide was rapidly (approximately 90%) absorbed, with peak blood and plasma(More)
The influence of dose volume on drug absorption following oral administration of a highly and a poorly water soluble drug was examined in male Sprague-Dawley rats. A constant mass of each 14C-labeled compound was given via gavage in dose volumes of 1, 5, 10, and 20 mL kg-1. Blood levels, as well as the quantitative excretion of radioactivity, were measured(More)
Water intake, muricidal behavior, irritability to handling, and open-field activity were assessed in Long-Evans male hooded rats subjected to either septal damage or control operations. Because of a failure to observe increased water intake after septal damage, it was concluded that increased water intake was not necessary for the display of either the(More)
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