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We investigate different test procedures for testing the difference of two Poisson means. Asymptotic tests, tests based on an approximate p-value method, and a likelihood ratio test are considered. Size and power performance of these tests are studied by means of Monte Carlo simulation under different settings. If one wants to control the actual… (More)

- Lewis A Fraser, Andrew B Kinghorn, Marco S L Tang, Yee-Wai Cheung, Bryce Lim, Shaolin Liang +2 others
- Molecules
- 2015

The functionalisation of microbeads with oligonucleotides has become an indispensable technique for high-throughput aptamer selection in SELEX protocols. In addition to simplifying the separation of binding and non-binding aptamer candidates, microbeads have facilitated the integration of other technologies such as emulsion PCR (ePCR) and Fluorescence… (More)

DNA aptamers have potential for disease diagnosis and as therapeutics, particularly when interfaced with programmable molecular technology. Here we have combined DNA aptamers specific for the malaria biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) with a DNA origami scaffold. Twelve aptamers that recognise PfLDH were integrated into a… (More)

Inverse sampling suggests one continues to sample subjects until a pre-specified number of rare events of interest is observed. It is generally considered to be more appropriate than the usual binomial sampling when the subjects come sequentially, when the response probability is rare, and when maximum likelihood estimators of some epidemiological measures… (More)

This article investigates various multiple testing procedures for the testing of unity odds ratios from stratified studies. These procedures compare individual ordered p-values to a series of adjusted nominal levels, and are employed to distinguish between significance and insignificance in stratified studies. Three commonly used approaches for determining… (More)

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