M L Heidrick

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Cytokines are a heterogenous group of polypeptide mediators that have been associated with activation of numerous functions, including the immune system and inflammatory responses. The cytokine families include, but are not limited to, interleukins (IL-I alpha, IL-I beta, ILIra and IL-2-IL-15), chemokines (IL-8/ NAP-I, NAP-2, MIP-I alpha and beta,(More)
The age-related decline in immune function, which is thought to be responsible for the increased incidence with age of certain diseases, including cancer, has been attributed primarily to a loss of T-lymphocyte function. As free radical reactions may contribute to cellular deterioration and loss of cell function with age, we investigated the effect of(More)
Adenosine 3',5'-monophosphate, at a concentration of 40 micrograms per milliliter, inhibits the growth of HeLa and strain L cells in culture. The inhibition becomes progressively greater during the incubation of the cells. Adenosine 5'-monophosphate and adenosine, metabolites of adenosine 3',5'-monophosphate, do not affect the growth of either cell culture.(More)
The effect of the plerocercoid larvae of Spirometra mansonoides on hormone levels and the immune system of intact and hypophysectomized (Hx) rats was studied. Intact rats exhibited a decrease in serum growth hormone (GH) and thyroxine (T4) concentrations and a suppression of the humoral immune response 2 wk postinfection. At 4 and 9 wk postinfection,(More)