M. L. Gordei

  • Citations Per Year
Learn More
The displacement curves of the effect of GABA on the S35-tert-butyl bicyclophosphorothionate binding to the brain membranes of inbred mice were analysed. It was revealed the lack of marked interstrain differences in dependent on the ionic force of incubation medium modification of IC50. After incomplete stimulation of Cl(-)-ionophore subunit (50 mM NaCl)(More)
The membrane fraction of the brain was isolated and washed as described previously [i]. Only freshly isolated preparations were used. The residue was resuspended in 50 mM Triscitrate buffer, pH 7.4, on the basis of the calculation that on the addition of an aliquot with a volume of 1 ml the protein concentration would be 400-600 Dg, and the concentration of(More)
Comparative study of effects of ionic concentrations on [35S]-TBPS binding was performed on brain membranes of inbred mice. It was shown that low concentrations of LiCl (less than 100 mM) were more stimulatory effective in Balb/c (C) mice than in C57Bl/6 (B6) mice. On the contrary, stimulatory activity of NaNO (less than 100 mM) was more pronounced in B6(More)
The influence of sodium chloride and gamma-aminobutyric acid (GABA) on H3-diazepam binding in CNS membrane fraction were investigated in C57Bl/6, BALB/c mice and their F1 hybrids. The addition of GABA (1, 10 and 100 microM) elevated the level of radioligand binding with CNS membranes in all the inbred mice in similar manner. The higher stimulating effect of(More)
3. L.V. 4. A.P. 5. V.P. 6. V. 7. V. 8. R. 9. D. 10. N. Maksimenko and V. P. Shchipkov, Byull. t~ksp. Biol. Meal., No. 10, 470 (1985). Maksimenko, V. P. Shchipkov, and A. P. Pekhov, Molekul. Genet., No. 9, 43 (1986). Pekhov and V. P. Shchipkov, Usp. Sov. Genet., No. 14, 75 (1987). Shchipkov, N. I. Buyanova, G. I. Myandina, et al., ByuU. I~ksp. Biol. Med.,(More)
Recently antioxidant derivatives of 3-hydroxypyrldine have been characterized as neurotropic agents, posessing a number of properties similar to the benzodiazepine tranquilizers in their activity spectrum [2, 5]. One of the undesirable effects of benzodiazepines is their sedative action, most pronounced in the "active" type of stress reaction; it has been(More)
A study of the behavior of inbred animals under conditions of emotional stress, of the biochemical parameters of the stress reaction, and effects of benzodiazepine tranquilizers, conducted in the writers' laboratory showed that the character of the response to stress and manifestation of the action of BD depend on hereditary factors [3]. The aim of this(More)
Previous investigations of the central mechanisms of formation of inherited differences in responses to emotional stress and to benzodiazepine tranquilizers in experiments on C57BL/6 (B6) and BALB/c (C) mice have led to the discovery and description of the phenotypic variants of regulation of the benzodiazepine receptor complex by C1ions [1]. In the present(More)
The displacement curves of the effect of picrotoxin on the S35-tert-butyl bicyclophosphorothionate binding to the brain membranes of inbred mice C57Bl/6 and Balb/c were analysed. The marked interstrain differences between modifications of IC50 and nHill dependent on the ionic force of the incubation medium were revealed. After partial stimulation of the(More)