M L Demchuk

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Study of the content of products of lipid peroxidation, total lipid antioxidation activity, and superoxide dismutase activity in the tissue and blood of 31 patients (23 with gliomas and 8 with meningiomas) showed the level of malonic dialdehyde (MDA) in the tumor tissue to be significantly lower statistically than in the cerebral tissue. The MDA content was(More)
The level of lipid peroxidation products (malonic dialdehyde) is more than two times increased in the anterior chamber humor in patients with far advanced glaucoma in comparison with the well-developed stage. The level of the total antioxidant activity of humor is reliably lowered. A correlation has been revealed between the antioxidant activity of humor(More)
The relationship between lipid peroxidation products and the severity of arterial spasm was studied in 86 patients. For this, the level of radical production, the content of the end lipid peroxidation product malonic dialdehyde and the overall antioxidative activity of lumbar cerebrospinal fluid were determined during 24-hour Doppler monitoring of blood(More)
The interrelationship between the functional state of the CNS and brain metabolism was studied in animals following craniocerebral trauma. Lipid peroxidation and antioxidant activity of rabbit brain were investigated a day after craniocerebral trauma. An increase in conjugated dienes, TBA-reactive products (TBARP), and fluorescent Schiff bases (SchB), and a(More)
Tissue examinations of glial tumors in the human brain revealed that therein lipid peroxidation could be induced by using bivalent iron salts, which is indicated by higher malonic dialdehyde levels. The authors have demonstrated that the glioma tissue levels of iron were statistically lower than those in the brain tissue. The induction in tumor tissue does(More)
The article deals with the results of study of the level of medium-size molecules in blood and urine of neurosurgical patients in the early postoperative period. It correlated with the severity of the patients' condition and with the values of osmolarity and the level of consciousness in a complicated postoperative period and a fatal outcome. The presence(More)
The method of chemiluminescence was applied for the determination of free radicals content in rabbit brain after the experimental craniocerebral trauma. The level of malondialdehyde was measured spectrophotometrically. The quantity of free radical products in hemispheres, brain stem and cerebellum of rabbits with traumatic injury was shown to be(More)
Interrelationship between the functional state of central nervous system and brain metabolism was studied in animals with craniocerebral trauma. Stimulation of nervous activity was shown to prevent an increase in lipid peroxidation in brain of the experimental animals. A distinct decrease of the brain antioxidative activity was also noted. Lipid(More)