BACKGROUND Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders because of the lack of sensitive biomarkers in serum. Fibroblast growth factor 21 (FGF-21) is a growth factor with regulatory roles in lipid metabolism and the starvation response, and concentrations are raised in skeletal muscle and serum in mice with mitochondrial… (More)
A strategy and toolset (FixIT) for migrating a specific type of legacy systems--based on the FileMan DBMS of the U.S. Department of Veterans Affairs--to a two-tier client/server and web browser-based architecture was presented in MEDINFO'98. In the current paper we discuss the further migration to a multitier software component architecture. A literature… (More)
We studied the genetic background of a family with SCA, showing dominant inheritance and anticipation. Muscle histology, POLG1 gene sequence, neuropathology and mitochondrial DNA analyses in a mother and a son showed typical findings for a mitochondrial disorder, and both were shown to be homozygous for a recessive POLG1 mutation, underlying mitochondrial… (More)
The majority of hospital information system installations in Finland are based on a legacy technology from the U.S. Department of Veterans Affairs (VA). This paper presents an architecture and a tool set which provide a migration path from terminal-based to client/server technology, conserving much of the investments in existing applications. It is argued,… (More)
Research on children and youth involved in migration in Asia is predominantly—and understandably—concerned with those move to improve their livelihoods. This includes those young people who move with their families as well as the effects on those 'left behind'. Substantial routes and streams include rural-to-urban migration to the burgeoning factory by… (More)
2013 Articlesinrefereedscientificjournals 1. P.R. Adhikari and J. Hollmén. Fast progressive training of mixture models for model selection. Using simulations and data to evaluate mean sensitivity ($$) as a useful statistic in dendrochronology.linear canonical correlation for joint analysis of MEG signals from two subjects.
The Cacophony around Community Community still seems to be a fashionable and meaningful word today although an increasing number of scholars claim that communities are threatened by globalisation and hypermodernity (see e.g. Dyck 2002: 106). A few examples: The national Finnish newspaper, Helsingin Sanomat, organized in 2011 a competition to determine the… (More)