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The effect of induced hypertension treatment on cerebral ischemia is still controversial. We investigated the preferred blood pressure manipulation level and pressor agent required to reduce cerebral ischemic injury following transient forebrain ischemia induced by bilateral occlusion of the common carotid arteries in anesthetized gerbils. Following 60-min(More)
Hemorheologic changes from silent to acute and chronic cerebral infarction have seldom been reported. We evaluated hemorheologic profiles of the whole blood viscosity, plasma viscosity and fibrinogen level in stroke at-risk patients with silent cerebral infarction, patients with acute or chronic cerebral lacunar infarction, and subjects at low risk for(More)
Whether nimodipine improves cerebral blood flow (CBF) and metabolism in cerebral ischemia remains a controversial issue. We investigated the effect of nimodipine on CBF, brain energy metabolism, using a laser-Doppler flowmeter and in vivo 31phosphorus nuclear magnetic resonance (31P NMR) spectroscopy, and blood rheology during forebrain ischemia and(More)
A 65-year-old man was admitted to our hospital because of a transient cerebral ischemic attack. Cranial CT and MRI showed no specific abnormality. Carotid imaging was performed with a newly developed convergent color Doppler (CCD), which images information on both flow velocity and Doppler signal energy simultaneously. These correspond to frequency shift(More)
OBJECTIVES To evaluate the effects of infusion with hyperosmolar solutions, mannitol and glycerol on the recovery of cerebral energy metabolism during ischemia and reperfusion in the gerbil brain. MATERIALS AND METHODS Sequential changes in cerebral energy metabolism following 90-min ischemia and up to 8 h after reperfusion were measured in 15 gerbils(More)
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