M Kate Borland

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Alzheimer's disease (AD) is characterized by the deposition in brain of beta-amyloid (Abeta) peptides, elevated brain caspase-3, and systemic deficiency of cytochrome c oxidase. Although increased Abeta deposition can result from mutations in amyloid precursor protein or presenilin genes, the cause of increased Abeta deposition in sporadic AD is unknown.(More)
We created and studied new cybrid cell lines from sporadic Alzheimer's disease (SAD) or control (CTL) subjects to assess mitochondrial abnormalities just after metabolic selection ("early passage") and again six passages later ("late passage"). Cytochrome oxidase (CO) activities in early passage SAD cybrids created independently from the same platelet(More)
The Linac Coherent Light Source (LCLS) is a fourth-generation light source demonstration project based on the self-amplified spontaneous emission (SASE) free-electron laser (FEL) concept. It will combine a new photoinjector, the Stanford Linear Accelerator Center (SLAC) linac, with two stages of bunch compression and a long undulator to create intense(More)
The high quality LCLS electron beam generated in the photoinjector is subject to many insta-bilities in the downstream acceleration and compression. The instability can be initiated by any density modulation of the electron beam generated at the photocathode. In this paper, we prescribe the tolerance on the initial electron beam density modulation possibly(More)
Experimental facilities for picosecond X-ray spectroscopy and scattering based on RF deflection of stored electron beams face a series of optical design challenges. Beamlines designed around such a source enable time-resolved diffraction, spectroscopy and imaging studies in chemical, condensed matter and nanoscale materials science using(More)
The Short Pulse X-ray facility planned for the Advanced Photon Source (APS) upgrade will provide two sectors with photon beams having picosecond pulse duration. The Short Pulse Soft X-ray Spectroscopy (SPSXS) beamline will cover the 150-2000 eV energy range using an APS bending magnet. SPSXS is designed to take full advantage of this new timing capability(More)