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BACKGROUND Vitamin D insufficiency is common in women of childbearing age and increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be determined partly by environmental factors during intrauterine and early postnatal life. We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth.(More)
OBJECTIVES To test whether bisphosphonate use is related to improved implant survival after total arthroplasty of the knee or hip. DESIGN Population based retrospective cohort study. SETTING Primary care data from the United Kingdom. PARTICIPANTS All patients undergoing primary total arthroplasty of the knee (n = 18,726) or hip (n = 23,269) in(More)
This paper describes a novel 3-D segmentation technique posed within the Random Forests (RF) classification framework. Two improvements over the traditional RF framework are considered. Motivated by the high redundancy of feature selection in the traditional RF framework, the first contribution develops methods to improve voxel classification by selecting(More)
OBJECTIVES To identify patient characteristics and surgical factors associated with patient-reported outcomes over 5 years following primary total hip replacement (THR). DESIGN Prospective cohort study. SETTING Seven hospitals across England and Scotland. PARTICIPANTS 1431 primary hip replacements for osteoarthritis. MAIN OUTCOME MEASURES The Oxford(More)
BACKGROUND National and international guidance emphasizes the need for hospitals to have effective secondary fracture prevention services, to reduce the risk of future fractures in hip fracture patients. Variation exists in how hospitals organize these services, and there remain significant gaps in care. No research has systematically explored reasons for(More)
Osteoporosis is a common skeletal condition that results in significant morbidity, mortality and health care costs. There is an increased awareness of bone health in people with severe mental illness (SMI). These people appear to be at a higher risk of low bone density and fracture, and also have a poorer outcome following hip fracture. The reason for the(More)
BACKGROUND Maternal vitamin D status has been associated with bone mass of offspring in many, but not all, observational studies. However, maternal vitamin D repletion during pregnancy has not yet been proven to improve offspring bone mass in a randomised controlled trial. We aimed to assess whether neonates born to mothers supplemented with vitamin D(More)
UNLABELLED Using a large cohort of hip fracture patients, we estimated hospital costs to be £14,163 and £2139 in the first and second year following fracture, respectively. Second hip and non-hip fractures were major cost drivers. There is a strong economic incentive to identify cost-effective approaches for hip fracture prevention. INTRODUCTION The(More)