M. Kassim Javaid

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OBJECTIVES To test whether bisphosphonate use is related to improved implant survival after total arthroplasty of the knee or hip. DESIGN Population based retrospective cohort study. SETTING Primary care data from the United Kingdom. PARTICIPANTS All patients undergoing primary total arthroplasty of the knee (n = 18,726) or hip (n = 23,269) in(More)
This paper describes a novel 3-D segmentation technique posed within the Random Forests (RF) classification framework. Two improvements over the traditional RF framework are considered. Motivated by the high redundancy of feature selection in the traditional RF framework, the first contribution develops methods to improve voxel classification by selecting(More)
OBJECTIVES To identify patient characteristics and surgical factors associated with patient-reported outcomes over 5 years following primary total hip replacement (THR). DESIGN Prospective cohort study. SETTING Seven hospitals across England and Scotland. PARTICIPANTS 1431 primary hip replacements for osteoarthritis. MAIN OUTCOME MEASURES The Oxford(More)
BACKGROUND National and international guidance emphasizes the need for hospitals to have effective secondary fracture prevention services, to reduce the risk of future fractures in hip fracture patients. Variation exists in how hospitals organize these services, and there remain significant gaps in care. No research has systematically explored reasons for(More)
Osteoporosis is a common skeletal condition that results in significant morbidity, mortality and health care costs. There is an increased awareness of bone health in people with severe mental illness (SMI). These people appear to be at a higher risk of low bone density and fracture, and also have a poorer outcome following hip fracture. The reason for the(More)
UNLABELLED MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR. BACKGROUND Osteoporosis is a major public health problem as a result of associated fragility fractures. Skeletal strength increases from birth to a peak in early adulthood.(More)
  • V I T, Francis Roger, Terry Aspray, William Fraser, Neil Gittoes, Kassim Javaid +5 others
  • 2013
There is growing interest in the importance of vitamin D, not only in the maintenance of bone health but also in terms of its potential role in the prevention of nonskeletal disorders such as auto-immune disease, cancer, mental health problems and cardiovascular disease. Although there is no universal consensus on the criteria for vitamin D deficiency, it(More)
BACKGROUND Maternal vitamin D status has been associated with bone mass of offspring in many, but not all, observational studies. However, maternal vitamin D repletion during pregnancy has not yet been proven to improve offspring bone mass in a randomised controlled trial. We aimed to assess whether neonates born to mothers supplemented with vitamin D(More)