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We present a method for the noninvasive determination of the size, position, and optical properties (absorption and reduced scattering coefficients) of tumors in the human breast. The tumor is first detected by frequency-domain optical mammography. It is then sized, located, and optically characterized by use of diffusion theory as amodel for the(More)
We present a novel approach to optical mammography and initial clinical results. We have designed and developed a frequency-domain (110-MHz) optical scanner that performs a transillumination raster scan of the female breast in approximately 3 min. The probing light is a dual-wavelength (690 and 810 nm, 10-mW average power), 2-mm-diameter laser beam, and the(More)
Frequency-domain optical mammography has been advocated to improve contrast and thus cancer detectability in breast transillumination. To the best of our knowledge, this report provides the first systematic clinical results of a frequency-domain laser scanning mammograph (FLM). The instrument provides monochromatic light at 690 and 810 nm, whose intensity(More)
  • Okkyun Lee, Jong Chul Ye, D D A H Boas, E L Brooks, C A Miller, M Dimarzio +123 others
  • 2013
Some optical properties of a highly scattering medium, such as tissue, can be reconstructed non-invasively by diffuse optical tomogra-phy (DOT). Since the inverse problem of DOT is severely ill-posed and nonlinear, iterative methods that update Green's function have been widely used to recover accurate optical parameters. However, recent research has shown(More)
We investigate the feasibility of trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator that is to be integrated with a trans-rectal ultrasound (TRUS) probe. Integration with TRUS ensures accurate endo-rectal positioning of the NIR applicator and the utility of using TRUS spatial prior information to guide NIR(More)
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