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Phenylephrine exerted a positive chronotropic and inotropic effect on isolated, spontaneously beating, atria of reserpinised rabbits. Addition of phenoxybenzamine and phentolamine resulted in a depression of control contractile amplitude. Practolol, however, was devoid of this effect. The positive inotropic response to phenylephrine was significantly(More)
for geriatric patients. The negative inotropic effect of sympathomimetic amines has scarcely been reported in rature. Wenzel and Su (3), while studying the interactions of sympathomimetic amines with ir antagonists on isolated rat ventricular strips, observed that phenylephrine initially produceda negative inotropic effect which was later on followed by(More)
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