M. João Monteiro

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A selected ion monitoring gas chromatography-mass spectrometry (GC-MS) procedure was developed to determine the interaction product formed by acrylonitrile (ACN) with the N-terminal amino group in haemoglobin. The product, N-(2-cyanoethyl)valine (CEV), was analysed following its release from the protein by a modified Edman degradation procedure.(More)
Quercetin has been the subject of numerous studies on its genetic toxicity and carcinogenicity. Despite its well-proven genetic damaging activity for various genetic end-points (reverse mutations, induction of SOS functions, induction of sister chromatid exchanges, chromosomal aberrations and micronuclei), the mechanisms of genetic damage by quercetin(More)
Epidemiological studies have led to the suggestion that a genetic basis may exist in the individual variation in predisposition to cancer. Interindividual differences in human toxicological response to carcinogenic exposure have been attributed to heritable polymorphisms in metabolism, namely glutathione S-transferases (GSTs) coding for enzymes that are(More)
Various studies have shown the mutagenicity of red wine. The major mutagens identified in red wine have been flavonoids, i.e. rutin and its aglycone quercetin. Besides flavonoids, however, it has recently been reported that H2O2 may account for the mutagenicity of red wine in the L-Arabinose resistance test. In the present study we report on the role of(More)
— Multi-player games are increasingly popular in the Internet. This growing interest results in the need to support a high number of participants, which raises the issue of scalability, namely in what regards the ability to offer good performance in such a large-scale setting. This paper addresses the issue of designing middleware solutions to support(More)
Resumo Actualmente, existe uma grande preocupação em dotar as aplicações distribuídas de mecanismos de tolerância a faltas. Neste artigó e apresentada uma possível integração de um jogo de computador multi-utilizador com um sistema de chamadas a procedimentos remotos a servidores repli-cados, de forma a tornar o jogo tolerante a faltas. 1 Introdução Uma(More)
In the present work we studied acrylonitrile (AN) occupationally exposed populations and respective control individuals working in a Portuguese plant producing acrylic textile fibers. Three subgroups of individuals were considered: controls (C), workers of the continuous polymerization (CP) area, and workers of equipment maintenance (MM). Besides aiming to(More)
Phenolic compounds and biogenic amines are known to be present in some foodstuffs which become directly genotoxic after nitrosation in vitro. Red wine has previously been shown to be genotoxic and this activity has been attributed mainly to flavonoids. Besides flavonoids, red wine contains a multiplicity of compounds, including biogenic amines. Using the(More)
Resumo Este artigo descreve um serviço transparente de suportè a replicação activa de servido-res CORBA, que opera sobre qualquer servidor/cliente sem requerer a recompilação de código. A concretização recorre a um sistema de comunicação em grupo disponível na plataforma de suportè a comunicação Appia. 1 Introdução O Common Object Request Broker(More)
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