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The pull-in voltage instability associated with a simple MEMS device, consisting of a thin dielectric elastic membrane supported above a rigid conducting ground plate, is analyzed. The upper surface of the membrane is coated with a thin conducting film. In a certain asymptotic limit representing a thin device, the mathematical model consists of a nonlinear(More)
We present a formalism for unifying the inference of population size from genetic sequences and mathematical models of infectious disease in populations. Virus phylogenies have been used in many recent studies to infer properties of epidemics. These approaches rely on coalescent models that may not be appropriate for infectious diseases. We account for(More)
Thirty years after the discovery of HIV-1, the early transmission, dissemination, and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa (in what is now the Democratic Republic of Congo) was the focus of early transmission and(More)
Antimicrobial resistance (AMR) in humans is inter-linked with AMR in other populations, especially farm animals, and in the wider environment. The relatively few bacterial species that cause disease in humans, and are the targets of antibiotic treatment, constitute a tiny subset of the overall diversity of bacteria that includes the gut microbiota and vast(More)
Spatio-temporal dynamics associated with a class of coupled membrane-bulk PDE-ODE models in one spatial dimension is analyzed using a combination of linear stability theory, numerical bifurcation software, and full time-dependent simulations. In our simplified 1-D setting, the mathematical model consists of two dynamically active membranes, separated(More)
Detailed laboratory characterization of Escherichia coli O157 is essential to inform epidemiological investigations. This study assessed the utility of whole-genome sequencing (WGS) for outbreak detection and epidemiological surveillance of E. coli O157, and the data were used to identify discernible associations between genotypes and clinical outcomes. One(More)
  • Rajesh Bagchi, Lauren G Block, Lauren, G Block, Ibrahim Karabiyik, Chrissy Mitakakis +3 others
  • 2011
This article examines how imputed costs influence food consumption. Across one field study and three lab studies, the authors demonstrate that the greater the imputed cost of consumption, the greater is the likelihood of choosing a more indulgent, high-calorie food. Specifically, the authors show that when the imputed costs of payment are higher, such as(More)
Phylogenies of highly genetically variable viruses such as HIV-1 are potentially informative of epidemiological dynamics. Several studies have demonstrated the presence of clusters of highly related HIV-1 sequences, particularly among recently HIV-infected individuals, which have been used to argue for a high transmission rate during acute infection. Using(More)
BACKGROUND Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared with HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there is no generally accepted strategy for identifying these patients. METHODS We retrospectively analysed 270 consecutively(More)