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  • Influence
4-Hydroxylation of estrogens as marker of human mammary tumors.
  • J. Liehr, M. J. Ricci
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 16 April 1996
Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those tissues in which this hormone is predominantly converted to the catecholExpand
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4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.
Estradiol is converted to catechol estrogens via 2- and 4-hydroxylation by cytochrome P450 enzymes. 4-Hydroxyestradiol elicits biological activities distinct from estradiol, most notably an oxidantExpand
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Cytochrome P450 metabolism of estradiol in hamster liver and kidney.
Estradiol induces kidney tumors in Syrian hamsters. The elevated conversion of estradiol to 4-hydroxylated metabolites in kidney compared to the predominant 2-hydroxylation in liver and other organs,Expand
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Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced
Estrogen-induced tumors in kidneys of male Syrian hamsters have been postulated to arise from cells which are damaged by free radicals and other reactive species generated during metabolic redoxExpand
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Cavernous tissue antibiotic levels in penile prosthesis surgery.
A comparison of the delivery of several antibiotics (vancomycin, gentamicin and aztreonam) to the tissue site of prosthesis implantation was studied using cavernous tissue levels for each antibiotic.Expand
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Effect of combined testosterone and estradiol‐17β treatment on the metabolism of E2 in the prostate and liver of noble rats
Long‐term treatment of Noble (NBL) rats with testosterone (T) and estradiol‐17β (E2) induces dysplasia in the dorsolateral lobe (DLP) but not in the ventral lobe (VP) of the rat prostate. The aim ofExpand
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Photolithographic Patterning of Ring-Opening Metathesis Catalysts on Silicon†
[23] Moreover, we also stress that the red-shifted emission could be not due to defects and/or impurities, because all the investigated compounds have been synthesized and purified with the sameExpand
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