M. J. Powell

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The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand-regulated modular nuclear receptor governing prostate cancer cellular proliferation, differentiation, and apoptosis in response to androgens, including dihydrotestosterone (DHT). Here, SIRT1(More)
Endocrine signaling via nuclear receptors (NRs) is known to play an important role in normal physiology as well as in human tumor progression. Hormones regulate gene expression by altering local chromatin structure and, thereby, accessibility of transcriptional co-regulators to DNA. Recently it has been shown that non-histone proteins involved in hormone(More)
IL-10 is an 18-kDa cytokine with a key role in homeostatic control of inflammatory and immune responses. We have investigated how transcription of the IL-10 gene is regulated, so as to be able to understand the circumstances of IL-10 expression in both health and disease. In the mouse, IL-10 gene expression is regulated by a TATA-type promoter with a(More)
INTRODUCTION Cyclin D1 is a member of the cyclin-dependent kinase (Cdk) family of serine/threonine kinases that play a pivotal role in controlling progression through the cell cycle (Pines, 1991; Motokura and Arnold, 1993). As the regulatory subunits of the Cdks, cyclin D1 complexes with catalytic partners to phosphorylate several different " pocket "(More)
The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb,(More)
The PC12 pheochromocytoma cell line responds to nerve growth factor (NGF) by exiting from the cell cycle and differentiating to induce extending neurites. Cyclin D1 is an important regulator of G1/S phase cell cycle progression, and it is known to play a role in myocyte differentiation in cultured cells. Herein, NGF induced cyclin D1 promoter, mRNA, and(More)
In our prior publications we characterized a conserved acetylation motif (K(R)xxKK) of evolutionarily related nuclear receptors. Recent reports showed that peroxisome proliferator activated receptor gamma (PPARγ) deacetylation by SIRT1 is involved in delaying cellular senescence and maintaining the brown remodeling of white adipose tissue. However, it still(More)
We consider trust region methods for seeking the unconstrained minimum of an objective function F (x), x ∈ R n , when the gradient ∇F (x), x ∈ R n , is available. The methods are iterative with x 1 being given. The new vector of variables x k+1 is derived from a quadratic approximation to F that interpolates F (x k) and ∇F (x k), where k is the iteration(More)
We propose a method for producing a truly seamless tiled image sensor from four identical subarrays, such that the resulting tiled image sensor has no missing pixels. Four standard amorphous silicon photodiode-TFT (thin film transistor) arrays are cut parallel to the bus-bars, in the space between the bus-bar and the preceding pixel electrode. The cut is(More)
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