M. J. Moreta

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Antiangiogenesis has become a promising pillar in modern cancer therapy. This study investigates the antiangiogenic effects of the PEGylated Adnectin™, CT-322, in a murine Colo-205 xenograft tumor model. CT-322 specifically binds to and blocks vascular endothelial growth factor receptor (VEGFR-2). Adnectins are a novel class of targeted biologics engineered(More)
The definition of stability for Runge–Kutta–Nyström methods applied to stiff second-order in time problems has been recently revised, proving that it is necessary to add a new condition on the coefficients in order to guarantee the stability. In this paper, we study the case of second-order in time problems in the nonconservative case. For this, we(More)
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