M. J. Martinez

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We have designed a special dynamometer for measuring mouse forelimb muscle strength and endurance. The device exploits a mouse's tendency to grasp a horizontal metal bar while suspended by its tail. A threshold value for the magnitude and duration of force that the mouse can exert is obtained by first allowing the animal to grasp the bar and then applying a(More)
Some kinetic properties of the microsomal cholesterol ester hydrolase (CEH) have been examined in rat liver. The reaction was linear with time up to 60 min and with enzyme concentration up to 0.3 mg/mL, and a pH optimum of 6.7 for enzyme activity was observed. Cholesterol esterase exhibited the following apparent kinetic constants: Km, 68.88 microM and(More)
In this paper, we consider the flow of an incompressible fluid in a deformable porous solid. We present a mathematical model using the framework offered by the theory of interacting continua. In its most general form, this framework provides a mechanism for capturing multiphase flow, deformation, chemical reactions and thermal processes, as well as(More)
Pore scale analysis of the impact of mixing-induced reaction dependent viscosity variations" (2012). a b s t r a c t Expanding interest in enhanced subsurface natural resource recovery and carbon sequestration motivates study of reacting flows in porous media. In this work, we examine the case of reaction products that increase or decrease the viscosity of(More)
  • Frank D Hansen, Ernest L Hardin, Robert P Rechard, Geoffrey A Freeze, David C Sassani, Patrick V Brady +20 others
  • 2010
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Lidocaine is a drug that blocks the sodium channel in a pH, frequency and concentration dependent manner. In this work, we have used a mathematical model of lidocaine developed by our group and incorporated it into the Luo Rudy model of ventricular action potential. We have studied the action of lidocaine on the sodium current (I Na), maximum upstroke(More)