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Simian virus 40 (SV40) replicates in nuclei of human and monkey cells. One viral protein, large tumour (T) antigen, is required for the initiation of DNA replication. The development of in vitro replication systems which retain this property has facilitated the identification of the cellular components required for replication. T antigen recognizes the(More)
When a human grasps a cylindrical object, feedback on the orientation of the cylinder with respect to the axes of the digits is crucial for successful manipulation of the object. We measured the ability of humans to discriminate the orientations of cylinders passively contacting the fingerpad. For a cylinder of curvature of 521 m-1 (radius, 1.92 mm)(More)
  • Tonghuan Hu, Patricia Foxworthy, Angela Siesky, James V Ficorilli, Hong Gao, Shuyu Li +7 others
  • 2005
Peroxisomes are the exclusive site for the ␤-oxidation of very-long-chain fatty acids of more than 20 carbons in length (VL-CFAs). Although the bulk of dietary long-chain fatty acids are oxidized in the mitochondria, VLCFAs cannot be catabolized in mitochondria and must be shortened first by peroxisomal ␤-oxidation. The regulation of peroxisomal,(More)
To determine which chromosomes and chromosomal regions contain putative tumor suppressor genes important for human epithelial ovarian cancer, we performed loss of heterozygosity (LOH) studies on 37 primary epithelial ovarian tumors. Using 70 polymorphic markers, we examined all chromosome arms (excluding acrocentric arms) on all specimens. Our findings show(More)
The T antigen specified by SV40 virus is the only viral-encoded protein required for replication of SV40 DNA. T antigen has two activities that appear to be essential for viral DNA replication: specific binding to duplex DNA at the origin of replication and helicase activity that unwinds the two DNA strands. As judged by electron microscopy, DNA unwinding(More)
In addition to the aim of mapping and sequencing one human's genome, the Human Genome Project also intends to characterise the genetic diversity of the world's peoples. The Human Genome Diversity Project raises political, economic and ethical issues. These intersect clearly when the genomes under study are those of indigenous peoples who are already subject(More)