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During a serosurvey of domestic dogs in Tanzania, a rapid fluorescent focus inhibition test (RFFIT) and a liquid-phase blocking ELISA (LPBE) were used to measure rabies antibodies in vaccinated and unvaccinated dogs. Post-vaccination titres measured by LPBE correlated closely with those found by RFFIT. Of 567 unvaccinated dogs tested using the LPBE, 42(More)
European bat lyssavirus type 1a (EBLV-1a) was first identified in central France from a serotine bat (Eptesicus serotinus) collected at the end of 2002. Rabies was diagnosed by reference rabies diagnosis methods and molecular tools. Phylogenetic analysis of 14 viral isolates obtained from French bats infected with EBLV-1 between 1989 and the end of 2002(More)
A simplified hemi-nested reverse transcriptase polymerase chain reaction (hnRT-PCR) has been developed to determine specifically the European Bat Lyssavirus 1 (EBLV-1) nucleoprotein gene. The specificity of this method was determined by using the seven genotypes of lyssavirus by RT-PCR, Southern blot and sequence analysis. Compared to the rabies diagnostic(More)
In France, the passive surveillance of lyssaviruses in bats started in 1989, with the first positive case found in the East of the country. In 2000, the French bat rabies surveillance network in France was improved on the basis of the one used for the surveillance of fox rabies. The objectives of this network are to improve bat rabies surveillance by(More)
Mouse inoculation test (MIT) is a highly sensitive test for rabies diagnosis but slow and expensive. To detect rabies virus an in vitro technique using Neuro 2a cell culture (CC) was compared with MIT in two laboratories. In one laboratory, CC appeared to be on the whole more sensitive than MIT, nevertheless MIT was the only one to detect some positive(More)
Two rabies virus strains collected from naturally infected foxes in France in 1976 and 1986 were inoculated in 2 groups each consisting of 10 foxes (approximately 50 lethal doses50 mouse intracerebral per fox). Another 20 healthy foxes were kept in the same cages as the inoculated animals in order to study the transmission of both strains. All the(More)
A model in mice was developed in order to check if a resistance against rabies could be naturally and genetically selected in a line of mammals. A more resistant strain of mice (DBA/2) was identified. However, up to present, all attempts have failed in view to create a resistant strain of swiss mice in breeding individuals surviving to rabies infection.
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