M. I. Reynolds

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The regulatory benefit of apoptosis (activation-induced cell death, AICD) in T cells can be influenced by immunosuppressive agents. We examined this for mycophenolate mofetile (MMF, using it's active metabolite, mycophenolate (MPA)) compared with rapamycin (RAPA) and the calcineurin inhibitors (CI) cyclosporin (CYA) and FK506 (FK). Pure T cells from(More)
1. Shivering in the barbitone-anaesthetised cat exposed to a lowered ambient temperature was reduced by transient haemorrhagic or drug induced hypotension such that there was a positive correlation between mean arterial blood pressure and the intensity of shivering. 2. Shivering which had been reduced by haemorrhage could be restored by the reinfusion of(More)
In the unanaesthetized rat cardiac output, measured by a thermodilution technique, fell rapidly following a 4h period of bilateral hind-limb ischaemia. There was a significant positive correlation between body temperature and total cardiac output after injury. There were also striking changes in the distribution of cardiac output; for example, hepatic(More)
The changes in interstitial fluid osmolality in the injured tissues during and after bilateral hind-limb ischaemia have been studied in young rabbits. There was a marked tissue fluid hyperosmolality which was directly related to the period of ischaemia. The increase in osmolality could be attributed to increases in lactate and potassium concentration. The(More)
Previous studies have identified novel lymphoid phenotypes in the adult human liver and provided evidence to suggest that lymphoid differentiation can occur locally in this organ. The aim of this study was to examine the adult human liver for the presence of hematopoietic stem cells that may provide the necessary precursor population for local hematopoietic(More)
1. The object of this study was to determine whether inhibition of capacitative calcium entry is essential for relaxation of the mouse anococcygeus via the NO/cyclic GMP signalling pathway. 2. In intact muscles, thapsigargin (Tg; 100 nM)-induced tone was relaxed by NO, sodium nitroprusside (SNP), 8-Br-cyclic GMP, and nitrergic field stimulation. The(More)
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