M. I. Mikhailov

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The genotypes and subtypes of 205 HBV isolates collected during 1989-2002 in Estonia and 14 other regions of the former USSR were determined by sequencing and phylogenetic analysis of the S gene. The in Europe prevailing genotypes, A and D, were also circulating in the whole territory of the former USSR including Estonia and accounted for 18.5 and 81% of(More)
It is generally understood that hepatitis B and hepatitis C may be sexually transmitted. During the last decade there was a sharp growth of hepatitis B and C in Russia. In comparison to 1992 the incidence of hepatitis B in Russia rose two-fold and in 1999 there were 43.31 cases per 100,000 of population (in some cities up to 150/100,000 and even more). The(More)
Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of ATP-sensitive K channels in beta cells. Morphological methods (immunohistochemistry and sulfonylurea binding) were used to establish the cellular and subcellular location of SUR1 in human and rodent islets. In the human, mouse and rat pancreas, all endocrine cells of the islets were immunolabelled(More)
Antibody to hepatitis E virus of IgG class (anti-HEV IgG) is regularly detected in industrialized countries, where HEV is non-endemic, at levels not exceeding 2-3%; seropositive individuals are often found in certain groups of patients and professionals exposed to an increased risk of blood-borne infections. The present study was aimed at the identification(More)
Enterovirus 71 (EV71) is an emerging human pathogen causing massive epidemics of hand, foot and mouth disease with severe neurological complications in Asia. EV71 also circulates in Europe, however it does not cause large outbreaks. The reason for distinct epidemiological patterns of EV71 infection in Europe and Asia and the risk of EV71 epidemic in Europe(More)
The mechanisms of development of autoimmune diseases may be associated with a complex of genetic, immune, hormonal, and infectious factors. Autoimmune diseases include a wide range of systemic and organ-specific diseases, including autoimmune hepatitis (AIH). It is currently assumed that the pathogenesis of AIH is due to compromised immune regulation in the(More)
A total of 1331 persons aged 18-53 years were screened for specific markers of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in their blood, among them 656 primary blood donors, 256 plasmapheresis donors, 111 HBsAg carriers and 306 primary donors with only anti-HBc in the blood. According to the results of assays obtained with the use of(More)
AIM Determination of breadth of spread of hepatitis B and C viruses among members of 5 groups with high risk of infection. MATERIALS AND METHODS By enzyme immunoassay 3219 sera of members of groups with high risk of infection and 1541 sera of blood donors were studied for the presence of HBsAg and anti-HCV. In 5 risk groups were included: HIV-infected(More)