M. I. Clarkson

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The interconversion between inactive and active protein states, traditionally described by two static structures, is at the heart of signalling. However, how folded states interconvert is largely unknown due to the inability to experimentally observe transition pathways. Here we explore the free energy landscape of the bacterial response regulator NtrC by(More)
A computer simulation model demonstrating the effect of directional selection upon a simplified quantitative genetic character, is presented. Complementary homozygous parents were crossed to generate a fully heterozygous F1 population. Phenotypic truncation selection was effected upon the F2 and subsequent generations, and genotypic and phenotypic response(More)
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