M . I . Andersen

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The Nordic countries have a long tradition of registry-based epidemiological research. Many population-based health registries were established in the 1960s, with use of unique personal identifiers facilitating linkage between registries. In recent years, each country has established a national database to track prescription drugs dispensed to individuals(More)
OBJECTIVES To assess the risk of serious upper gastrointestinal bleeding associated with the newer antithrombotic agents used alone or in combination with other antithrombotic drugs; to describe the trends in use of antithrombotic drugs in the background population. DESIGN Population based case-control study. SETTING Funen County, Denmark (population(More)
OBJECTIVES Premature ejaculation (PE) is the most common ejaculatory dysfunction. We assessed the efficacy of sildenafil to increase the time to ejaculation, improve ejaculatory control, and decrease the postejaculatory erectile refractory time in men with PE. DESIGN AND METHODS The main study was an 8-week, double-blind, placebo-controlled, parallel(More)
PURPOSE To develop a pharmacoepidemiologic method for drug utilization analysis according to indication, gender, and age by means of register-based information. Statin utilization in 2005 was applied as an example. METHODS Following the recommendations for statin therapy, we constructed an indication hierarchy with eight mutually exclusive levels of(More)
OBJECTIVE To investigate the risks of adverse pregnancy and birth outcomes for treated and untreated bipolar disorder during pregnancy. DESIGN Population based cohort study using data from national health registers. SETTING Sweden. PARTICIPANTS 332,137 women with a last menstrual period anytime after 1 July 2005 and giving birth anytime before the end(More)
OBJECTIVE To define the optimum tamoxifen dose for reducing bicalutamide (CASODEX) 150 mg monotherapy-induced breast events (ie, gynaecomastia or breast pain or both) without compromising disease control. METHODS This was a double-blind, parallel-group, multicentre trial in which 282 patients with prostate cancer were randomised to receive bicalutamide(More)
PURPOSE To assess adverse events with use of antiepileptic drugs (AEDs) by the method of sequence symmetry analysis. METHODS We used data from two population-based sources in Funen County, Denmark (population 2006: 479,000); prescription data from Odense University Pharmacoepidemiological Database (OPED) for the period of 1 August 1990-31 December 2006,(More)
OBJECTIVE To evaluate the impact of feedback on the prescribing of antibiotics supplementary to clinical guidelines in the treatment of respiratory tract infections. DESIGN Randomised, controlled trial with GPs allocated to one of two groups. The first group received clinical guidelines on the treatment of respiratory tract infections plus postal feedback(More)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • A recent meta-analysis has suggested an increased risk of cancer among users of angiotensin receptor blockers. WHAT THIS STUDY ADDS • Within the limitations of an observational study there is no difference in the cancer incidence between users of drugs affecting the renin-angiotensin system and users of other(More)
BACKGROUND AND PURPOSE Selective serotonin reuptake inhibitors (SSRIs) have been associated with increased risk of bleeding complications, possibly as a result of inhibition of platelet aggregation. Little is known about the risk of intracerebral hemorrhage in users of SSRIs and whether the effect on platelet aggregation reduces the risk of ischemic stroke.(More)