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— General formulas of entanglement concentration are derived by using an information-spectrum approach for the i.i.d. sequences and the general sequences of partially entangled pure states. That is, we derive general relations between the performance of the entanglement concentration and the eigen-values of the partially traced state. The achievable rates(More)
To understand the significance of negative charges in the extracellular loops of the inwardly rectifying K(+) (Kir2.1) channel, single-point mutants (D112N, D114N, E125Q, D152E, D152K, D152N, E153D, E153K, and E153Q) and double-point mutants (D112N/D114N and D152N/E153Q) were constructed and transfected into COS-1 and HEK293 cells. All single-point mutants,(More)
Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K(+) channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the molecular candidates of functional K(+) channels in pancreatic duct cells, including KCNN4 (KCa 3.1), KCNMA1(More)
Effects of internal spermine on outward single-channel currents through a strongly inwardly rectifying K(+) channel (Kir2.1) were studied at asymmetrical K(+) concentrations (30 mm external and 150 mm internal K(+)). The current-voltage (I-V) relation for the single channel was almost linear and reversed at -37 ± 3 mV (V(R); n = 19). The channel conductance(More)
Adenosine modulates a wide variety of biological processes via adenosine receptors. In the exocrine pancreas, adenosine regulates transepithelial anion secretion in duct cells and is considered to play a role in acini-to-duct signaling. To identify the functional adenosine receptors and Cl− channels important for anion secretion, we herein performed(More)
Transient receptor potential vanilloid 1 (TRPV1) activation in peripheral sensory nerve is known to be associated with various pain-related diseases, thus TRPV1 has been the focus as a target for drug discovery. In this study, we characterized the pharmacological profiles of(More)
Quantum chemical calculations of geometric and electronic structure and vertical transition energies for several low-lying excited states of the neutral and negatively charged nitrogen-vacancy point defect in diamond (NV(0) and NV(-)) have been performed employing various theoretical methods and basis sets and using finite model NC(n)H(m) clusters. Unpaired(More)
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