M.H Wang

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The NAD(P)H quinone oxidoreductase (NQO1:EC is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have(More)
Although heat-shock protein 70 (Hsp70) has been considered an intracellular protein, we report that Hsp70 is secreted under normal cell culture conditions by human prostate cell lines, LAPC-4, PC-3, CWR-22, RWPE-1 and -2, LNCaP, and TRAMP (transgenic adenocarcinoma mouse prostate)-C2. We found that the secretion can be enhanced by transfection with cDNA(More)
  • R Hettel, K Bane, L Bentson, K Bertsche, S Brennan, Y Cai +15 others
  • 2008
SLAC is developing a long-range plan to transfer the evolving scientific programs at SSRL from the SPEAR3 light source to a much higher performing synchrotron source – PEP-X – a new storage ring that would occupy the existing PEP-II tunnel and support two experimental halls, each containing 16 x-ray beam lines. Operating at 4.5 GeV and 1.5 A with a(More)
Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against inflammatory bowel disease exploiting knowledge of common variants associated with the same disease. Through replication genotyping(More)
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