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The pathogenesis of multiple myeloma (MM), a neoplastic proliferation of monoclonal plasma cells, is a multi-step process with progressive acquisition of genetic aberrations. Disease initiation involves the activation of oncogenes such as D-type cyclins by chromosomal translocations involving the immunoglobulin (Ig) gene. Inactivation of tumor suppressor(More)
OBJECTIVES To determine if breast cancer risk in women with SLE is modified by a history of exposure to hormone replacement therapy (HRT) or oral contraceptives (OC), after adjusting for other risk factors. METHODS Data were pooled from SLE cohorts at three centres. For each female cohort member (n = 871), the probability of developing breast cancer was(More)
OBJECTIVE Previous studies have suggested that women with systemic lupus erythematosus (SLE) are at greater risk for cervical dysplasia than are women in the general population. However, the factors associated with abnormal Pap test results in SLE have not been well studied. We therefore aimed to determine the factors associated with lifetime occurrence of(More)
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