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Neuronal intranuclear inclusions are found in the brains of patients with Huntington's disease and form from the polyglutamine-expanded N-terminal region of mutant huntingtin. To explore the properties of inclusions and their involvement in cell death, mouse clonal striatal cells were transiently transfected with truncated and full-length human wild-type(More)
BACKGROUND AND PURPOSE There are a few reports regarding the outcome evaluation of balloon-expandable intracranial stent placement (BEICS). The purpose of our study was to evaluate the outcome and factors related to the adverse events (AEs) of BEICS. MATERIALS AND METHODS We evaluated 100 consecutive patients who underwent BEICS. We assessed the(More)
BACKGROUND Only a few clinical trials have been conducted in patients with advanced pancreatic cancer after failure of first-line gemcitabine-based chemotherapy. Therefore, there is no current consensus on the treatment of these patients. We conducted a randomised phase II study of the modified FOLFIRI.3 (mFOLFIRI.3; a regimen combining 5-fluorouracil(More)
An expansion of polyglutamines in the N terminus of huntingtin causes Huntington's disease (HD) and results in the accrual of mutant protein in the nucleus and cytoplasm of affected neurons. How mutant huntingtin causes neurons to die is unclear, but some recent observations suggest that an autophagic process may occur. We showed previously that huntingtin(More)
The dissociation of immediate and delayed word repetition was studied using a continuous recognition memory task and event-related potential (ERP). Among 240 stimulus words, 40 words were not repeated, 100 were immediately repeated and 100 were repeated after 5 intervening words. Words presented only once during the experiment were referred to as new words.(More)
OBJECTIVE To learn more about the behavioural and anatomical features of ipsilesional neglect. METHODS Thirty consecutive patients with spatial neglect were tested on cancellation and line bisection tasks. To learn if patients with ipsilesional neglect demonstrate the sensory-attentional or motor-intentional type of neglect, a video apparatus was used(More)
From a cohort of 8,080 patients with advanced gastric carcinoma (AGC), 13 patients who developed intracranial metastasis were evaluated retrospectively. The average age of onset of these patients was younger than that of remaining patients who did not appear to have intracranial metastasis. Five of these patients presented with leptomeningeal metastasis(More)
We investigated the role of excitatory amino acid receptors in mechanical hyperalgesia induced by subcutaneous injection of Freund's complete adjuvant (FCA) into the rat hind paw. In normal rats, an intraplantar (i.pl.) injection of L-glutamate, but not of D-glutamate (3 pmol/0.1 ml each) produced a mechanical hyperalgesia in the hind paw with a lowered(More)
R-band intensity measurements along the light curve of Type Ia supernovae discovered by the Supernova Cosmology Project (SCP) are fitted in brightness to templates allowing a free parameter the time-axis width factor w ≡ s × (1 + 2 z). The data points are then individually aligned in the time-axis, normalized and K-corrected back to the rest frame, after(More)
The osteological and morphological variations of the prominences in the bony palate of 160 Korean skulls were studied. The frequency of the occurrence of the posterior palatine crest, located on the posterior border of the greater palatine foramen, was 13.8%. Palatal ridges were observed commonly in the skulls; however, the smooth type, which has no palatal(More)