M. H. Fleysher

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The compounds N6-allyl-, N6-isopropyl-, N6-propargyl-, and N6-(2-methylallyl)adenosine were prepared by reacting 6-chloropurine riboside with an excess of the corresponding amines in ethanol, in the presence of two acid acceptors resulting in virtually quantitative yields. The compounds showed biological activity in a number of in vitro and in vivo tumor(More)
pentenyl)adenosine (IPAR). The resistance was unaltered after 5 months maintenance in absence of the drug. S-180/KR cells showed increased sensitivity to certain purine and pyrimidine nucleoside analogs such as 6-thiopurine ribonucleoside and 5-fluorodeoxyuridine. The activity of purine nucleoside phosphorylase (purine nucleoside:orthophosphate(More)
pentenyl)adenosine (IPAR). The resistance was unaltered after 5 months maintenance in absence of the drug. S-180/KR cells showed increased sensitivity to certain purine and pyrimidine nucleoside analogs such as 6-thiopurine ribonucleoside and 5-fluorodeoxyuridine. The activity of purine nucleoside phosphorylase (purine nucleoside:orthophosphate(More)
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