M.H. Chen

Learn More
BACKGROUND AND PURPOSE The widely accepted MR method for quantitating brain tumor microvascular permeability, K(trans), is the steady-state T1-weighted gradient-echo method (ssT1). Recently the first-pass T2*-weighted (fpT2*) method has been used to derive both relative cerebral blood volume (rCBV) and K(trans). We hypothesized that K(trans) derived from(More)
BACKGROUND AND PURPOSE Glioblastoma multiforme (GBM) and single brain metastasis (MET) are the 2 most common malignant brain tumors that can appear similar on anatomic imaging but require vastly different treatment strategy. The purpose of our study was to determine whether the peak height and the percentage of signal intensity recovery derived from dynamic(More)
BACKGROUND Small molecule MIRA-1 induced mutant p53-dependent apoptosis in several types of solid tumours. However, anti-tumour activity of MIRA-1 in haematological malignancies including multiple myeloma (MM) is unknown. In this study, we evaluated the effect of MIRA-1 in MM. METHODS We examined the anti-tumour activity of MIRA-1 alone or in combination(More)
BACKGROUND The profiles of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) have never been explored. The aim of the study was to investigate the reflux profile in OSAHS patients. METHODS Consecutive snoring out-patients suspected with having OSAHS and 20 healthy volunteers(More)
Background/Purpose: The 85+-year-old population – the " oldest old " – is now the fastest growing age segment in Canada. Although existing research demonstrates high health services utilization and prescribed medications in this population , little epidemiological evidence is available to guide care for this age group. Objective: To describe the(More)
  • 1