M H Buytendorp

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The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infection in 1992 and 1993 was determined by testing 2,152 specimens from injection drug users living in 11 geographic areas in Spain. Results obtained by an authentic HTLV-1 and -2 test were compared with those obtained by an HTLV-1 assay. HTLV infection was identified in 7 of 11(More)
Clarithromycin1* (1, 6-O-methylerythromycin A, A-56268, TE-031) is a new macrolide currently undergoing clinical development. The excellent properties2) of 1 make it attractive for further synthetic modifications. It is knownthat, reduction of the 9-keto group of erythromycin A (2), for example with sodium borohydride, gives the corresponding secondary(More)
A novel complex of elfamycin-type antibiotics has been isolated from submerged fermentation of either Streptomyces violaceoniger AB 999F-80 or Streptomyces violaceoniger AB 1047T-33. Antibiotics were extracted from the fermentation broth with ethyl acetate and from the mycelia with acetone. Purification of individual components was achieved by a combination(More)
Tunichlorin, a blue-green pigment isolated from the Caribbean tunicate Trididemnum solidum, has been identified as nickel(II) 2-devinyl-2-hydroxymethylpyropheophorbide a by chemical and spectroscopic methods, with confirmation by partial synthesis of dimethyl tunichlorin from chlorophyll a. Nickel chlorins have been reported from geological sources but not(More)
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