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In order to study the central neurochemical control of the vagus nerve, the contents of glycine, GABA, glutamate and five other amino acids have been measured in ten anatomically distinct regions of the rat medulla oblongata. Additionally, the high affinity uptake of glycine, GABA, glutamate, and leucine were measured in the same ten medullary regions. The(More)
The distribution of monoamine transmitters among the nuclei of the caudal medulla was determined through the combined use of the Falck-Hillarp histofluorescence method for cellular localization of catecholamines and serotonin and quantitative micropunch neurochemical assays of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) content using(More)
The topographical distribution of glutamate uptake, GABA uptake, and GAD activity was studied in caudal, intermediate and rostral areas of the nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the hypoglossal nucleus (n.XII). Within the NTS and n.XII,(More)
Parameters affecting the binding of [3H]glycine to membrane fractions isolated from the cerebral cortex, midbrain, cerebellum, medulla oblongata, and spinal cord of the rat were investigated in a Na+-free medium. A [3H]glycine binding assay was established in which the binding was specific, saturable, pH-sensitive, and reversible. Conditions were chosen in(More)
The rostrocaudal extent of the preganglionic parasympathetics of the vagus nerve (DNV, the dorsal nucleus of the vagus, also called the dorsal motor nucleus of the vagus) was traced using the retrograde horseradish peroxidase (HRP) transport method. Labeled cells were found within, and both rostral and caudal to, the classically-defined DNV. Cell bodies of(More)
The cerebella of rats were exposed to selective doses of low levels of x-irradiation beginning on day 4, 8, or 12 following birth. The doses of x-irradiation given on days 12, 13, and 15 (12-15X group) resulted in a 24% reduction in the wet weight of the cerebella; the doses given on days 8, 9, 11, 13, and 15 (8-15X group) resulted in a 57% weight(More)