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The nucleoprotein (NP) is one of the main determinants of species specificity of influenza A viruses. Using 25 NP sequences we have constructed evolutionary trees by the strict-parsimony procedure of Fitch (197 1). In contrast to the evolutionarygene tree, the tree based on amino acid sequences unravels remarkable differences between avian and human NPs,(More)
The nucleoprotein (NP) genes of nine influenza A virus strains isolated from different species have been sequenced and the deduced amino acid sequences have been compared to published NP sequences and sequences in press. Two "subtypes" of NPs can clearly be defined, one "subtype" comprises the NPs found with all tested human and one porcine strain, and(More)
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