M. G. Rybakova

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OBJECTIVES To characterize dynamics of changes of serum levels of TGF-beta1 and TNF-alpha in rats with cardiac fibrosis (CF) occurring during chronic renal failure (CRF), and to reveal the character pf correlations of these factors with amounts of cardiac collagen. DESIGN AND METHODS CRF was induced by unilateral nephrectomy and by electrocoagulation of(More)
The authors present a review of clinicopathologic manifestations of the most important syndromes of terminal period. Insufficiency and failure of the heart, lungs, brain, kidneys, and liver as well as multiple organ failure are characterized. Precise definition in the autopsy report of the prevailing syndrome and type of death makes it possible to assess(More)
The concept of the incretory activity of the parotid and submandibular salivary glands stems from numerous clinical and experimental data indicating a close association between them, sex and pancreatic glands and the pituitary. The paper presents the data on the mechanism of action of the salivary glands hormone, parotine. The participation of the salivary(More)
The pathogenesis of diffuse toxic goiter has not yet been fully understood. The literature increasing commonly focusses on the issues related to the processes occurring in the thyroid gland itself: proliferation, apoptosis, and angiogenesis. AIM to investigate clinical and laboratory parameters, as well as the expression of Ki-67, Bcl-2, Bax, Fas-L, CD34,(More)
To evaluate prognostic value of morphometric studies of the stroma of transitional cell carcinomas of the renal pelvis and ureter, we studied retrospectively the data of primary examination and follow-up of 75 patients (49 males, 65% and 26 females, 35%; mean age 61.9 +/- 1.2 years) given radical surgical treatment for cancer of the renal pelvis and ureter.(More)
Principles of organization of St. Petersburg pathology service are outlined. The service covers the Consultative and Methodological Council, the Department of Management and 53 departments including 12 departments attached to the city pathology bureau. The main problems of the service concern inadequate financing and material-technical support, lack of(More)
The structural and metabolic indicators of the function of the end secretory divisions, intercalary ducts, and salivary tubes of the salivary gland were assayed in white rats aged 20 1/2 months. This age period is characterized by the occurrence of noticeable changes in the reproductive tract and of spontaneous tumors in different organs. Abnormalities of(More)
Papers on the significance of cardiomyocyte apoptosis in cardiovascular disorders development are reviewed. Some distinctive features of regulation and morphological manifestations of cardiomyocyte apoptosis are described. Although a great majority of cardiomyocytes are highly differentiated cells, apoptosis-related loss of cellular weight is noted in the(More)
Quantitative activity of oxidative-reductive and hydrolytic enzymes obtained during operation was investigated in different parts of the human submandibular salivary glands. Quantitative estimation of enzymic activity was done by photometry of the negatives prepared on MY-phi-6. Comparative examination of enzymatic activity made it possible to state that(More)