M. G. Klinnikova

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The morphogenesis of anthracycline-induced dilated cardiomyopathy was studied after single sublethal dose of doxorubicin. Cardiomyocyte depopulation (up to 27%) and decrease in their regeneratory plastic reactions were the main mechanisms of cardiac failure development after anthracycline (doxorubicin) treatment, determining the type of heart remodeling by(More)
The type and intensity of remodeling (structural reorganization) of the myocardium in Wistar rats were studied under conditions of experimental chronic dyslipidemia and verapamil treatment. Long (64 days) atherogenic diet caused dyslipidemia and led to reduction of the heart percent weight. The cytopathic effect of dyslipidemia manifested in more intense(More)
Single total hyperthemia changed the absolute number of cardiomyocytes in experimental animals. The total number of cardiomyocytes decreased by 20% (without signs of their necrosis) on day 3 of post-heating restitution and then returned to the control. This was probably related to cytokinesis (without karyokinesis) of binucleated cells, whose content(More)
The expression of mRNA of matricellular proteins (osteopontin, and lumican), apolipoproteins E and A-IV, and microsomal triglyceride transfer protein, and the intensity of fibroplastic processes were studied in the myocardium of rats during experimental chronic hypercholesterolemia. We have found that the development of chronic hypercholesterolemia was(More)
Remodeling of the myocardium in Wistar rats during aging is characterized by cardiomyocyte hypertrophy and increase of their total volume in the left ventricle; the total volume of the connective tissue also increases without marked changes in cardiomyocyte count and total volume of blood capillaries. The number of cardiomyocytes with contracture injuries(More)
We studied the peculiarities of lipid spectrum of the blood and structural reorganization of the myocardium in experimental hypercholesterolemia with and without hypothyroidism. It was found that alimentary hypercholesterolemia accompanied by elevated total cholesterol, LDL, HDL, and triglyceride concentrations led to a decrease in body weight, heart(More)
Ultrastructural changes in rat cardiomyocytes were studied after single administration of cyclophosphamide in the therapeutic dose. The major signs of cyclophosphamide-induced damage to cardiomyocytes included moderate lysis of myofibrils, dilation of vesicles in the granular and agranular sarcoplasmic reticulum, and destruction of mitochondria with the(More)
Structural reorganization of the myocardium is observed in CBA mice under conditions of hypogeomagnetic field (reduction by 105 times). Changes in tissue architectonics manifest themselves in a reduced capillary/cardiomyocyte volume ratio against the background of hemodynamic disturbances. Intracellular disturbances result from impaired regeneration(More)
We studied structural reorganization of the liver after toxic injury caused by a single injection of doxorubicin in a sublethal dose (10 mg/kg). The morphogenesis of doxorubicin injury to the liver is determined by two main pathogenetic factors: cytotoxic effect of doxorubicin and its metabolites on liver cell populations (primarily hepatocytes) and(More)